During an asthma attack, mucus plugging occurs due to...

During an asthma attack, mucus plugging occurs primarily due to increased production of mucus by goblet cells. In asthma, the airways become inflamed and hyperresponsive, leading to various changes in the respiratory system. The inflammation stimulates the goblet cells in the airway epithelium to produce an excessive amount of mucus. This overproduction contributes to the narrowing of the airways and the development of mucus plugs, which can obstruct airflow and exacerbate breathing difficulties during an asthma attack.

The increased mucus is a physiological response intended to trap inhaled allergens and irritants. However, in an asthmatic individual, this response becomes detrimental, as it contributes to airway resistance and obstructs airflow, which is a hallmark of asthma exacerbations.