Which substances do mast cells release when stimulated?

Mast cells play a significant role in the immune system, particularly in allergic reactions and asthma. When stimulated, mast cells release various mediators that contribute to the inflammatory response. The release of histamine and leukotrienes is particularly crucial in the context of asthma.

Histamine, released by mast cells, causes bronchoconstriction, increased vascular permeability, and mucus secretion, all of which can exacerbate asthma symptoms. This mediates the immediate hypersensitivity reactions typical in allergic asthma. Leukotrienes, on the other hand, are lipid-based mediators that not only promote bronchoconstriction but also attract other inflammatory cells to the site of inflammation, significantly contributing to the late-phase response in asthma attacks.

Understanding the role of these substances is critical for asthma educators since these mediators are targets for various asthma therapies, particularly leukotriene receptor antagonists and antihistamines, which can help manage and alleviate symptoms by blocking or counteracting these actions.